What is the TXA dose for adults with SBP < 90 and HR > 110 given within the first hour?

What is the TXA dose for adults with SBP < 90 and HR > 110 given within the first hour?

• A. 1 g IV/IO over 10 minutes
• B. 2 g IV/IO over 20 minutes
• C. 500 mg IV over 5 minutes
• D. 1 g IM over 10 minutes

Answer: (A)

Early use of tranexamic acid in severe trauma is about stopping the body’s excessive breakdown of clots as quickly as possible to reduce bleeding and improve survival. When an adult patient has SBP under 90 and HR over 110 and the injury is within the first hour, the recommended loading dose is 1 gram given IV or IO over about 10 minutes. This rapid IV/IO infusion provides fast antifibrinolytic effect exactly when bleeding is most dangerous. If the patient remains within the treatment window, a second dose of 1 gram is given over 8 hours. The other options don’t fit because they either overshoot the initial loading amount, under-dose, or use an inappropriate route (IM) that would slow and unpredictable absorption.

Early use of tranexamic acid in severe trauma is about stopping the body’s excessive breakdown of clots as quickly as possible to reduce bleeding and improve survival. When an adult patient has SBP under 90 and HR over 110 and the injury is within the first hour, the recommended loading dose is 1 gram given IV or IO over about 10 minutes. This rapid IV/IO infusion provides fast antifibrinolytic effect exactly when bleeding is most dangerous. If the patient remains within the treatment window, a second dose of 1 gram is given over 8 hours. The other options don’t fit because they either overshoot the initial loading amount, under-dose, or use an inappropriate route (IM) that would slow and unpredictable absorption.